P-5: Effect of Total and Severe Teratozoospermia on The Outcome of ICSI

s:1750:"Background: We propose in this work to assess the effect of total and severe teratozoospermia on the outcome of intra cytoplasmic sperm injection( ICSI) essentially the biological side and try to highlight the factor in the success or failure of the attempt in cases of extreme or total teratozoospermia. Materials and Methods: This is a comparative retrospective study including 140 couples who underwent medically assisted reproduction by the technique of ICSI identified in the unity of "assisted reproduction". This study includes two groups: one group comprising 100 couples in which the indication of ICSI is a total or extreme teratozoospermia (abnormal forms ≥ 97%) (Group I) and a group with 40 other couples for abnormal semen analysis (Group II). Results: The fertilization rates respectively in the teratozoospermia group and control group were 68% and 65%, segmentation rate were 96.9% and 97%, and top quality embryo were 70% and 81%. Those rates were similar for the group total and extreme teratozoospermia and the control group (DNS). The rate of maturation showed a significant difference with a rate of 70% in the study group and a rate of 86% in the control group (p= 0.01). In the group teratozoospermia, we found a significant difference in fertilization rate when an abnormality concerns the head or another part of the spermatozoid (p= 0.04). Concerning head abnormalities, we found also a significant difference in fertilization rate between acrosomial and non acrosomial abnormalities. Conclusion: Head and acrosomial seem to have a side effect on the biological results of ICSI in case of teratozoospermia. It does not seem to be a poor prognostic factor in the success of the attempt of ICSI.";